Randomized, Double-Blind, Placebo-Controlled, Stage II Trial of Acupuncture For Lung Cancer Patients With Cancer Related Fatigue(CRF)
Inclusion Criteria:
- Patients who are pathologically/cytologically diagnosed as NSCLC and received
radiotherapy with or without chemotherapy, and the last radio- or chemo-therapy must
be at least 30 days prior to initiation of experimental treatment;
- Participants who meet the diagnosis criteria of CRF(ICD-10 criteria);
- The first time to receive acupuncture treatment;
- The age is between 18 and 65 years old;
- Mean baseline fatigue as measured by the Brief Fatigue Inventory (BFI) must be four
or above;
- ECOG performance status 0, 1 or 2.
- Patients must have adequate organ functions reflected by the laboratory criteria
below: neutrophil counts ≥ 1.5×109 /L, platelet count ≥ 100 x 109/L, hemoglobin ≥ 85
g/L, Serum creatinine < 2.0 mg/dL, Bilirubin < 1.5 mg/dL, ALT < 3 x normal, albumin
>30g/L.
- Have not taken any hypnotic, melatonin, or antidepressants within 30 days;
- Willing to finish the whole observation period;
- With written consent form signed by themselves.
Exclusion Criteria:
- Participants in other clinical research;
- Can not be pathologically or cytologically diagnosed as NSCLC;
- ECOG 3~4;
- Pregnant woman;
- >65 or <18 years old;
- Patients with evidence of any cognitive dysfunction that would limit their abilities
to report fatigue;
- Patients who have received acupuncture ever before;
- Received surgery, immunotherapy or target therapy within one month before the
recruition;
- Taking warfarin or heparin, a bleeding tendency exists;
- Infection, ulceration or hyperalgesia at or near the local acupoints' skin,or with
active infections;
- There are cerebral vascular accident history or spinal cord injury history;
- Combination with other serious diseases or condition, including congestive heart
failure, Unstable angina pectoris, myocardial infarction during the past six months,
serious's arrhythmia, mental disorders, drug abuse, etc.;
- Patients with a life expectancy < 3 months;
- Patients with a past history of therapy or scheduled visits non-compliance, as
determined by their treating physician.