Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
This study has been done to further study the effectiveness of dexamethasone in the
prevention of postoperative emesis after breast and thyroid surgery and at the same time,
the mechanism of action was investigated. In this prospective, randomized controlled trial
it was hypothesized that corticosteroids exert their antiemetic effects in postoperative
period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4)
inhibition.
Observational
Observational Model: Case Control, Time Perspective: Prospective
Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis
participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.
up to 3 days
Yes
A.Ozdemir Aktan, MD,prof
Principal Investigator
Marmara University
Turkey: Ethics Committee
09.2011.0024
NCT01811199
February 2011
May 2013
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