Inclusion Criteria:

1. Adult patients 18 years of age or older

2. Patients presenting with a renal cell nodule or mass that are scheduled for open
resection based on clinical criteria

3. Good operative candidate

4. Subject capable of giving informed consent and participating in the process of
consent.

Exclusion Criteria:

1. Pregnant women as determined by urinary or serum beta human chorionic gonadotropin
(hCG) test within 72 hours of surgery

2. Patients with a history of anaphylactic reactions to Folate-FITC or insects

3. At-risk patient populations

1. People who would be easily lost to follow-up (ex: People who are homeless or
alcohol dependent)

2. Children and neonates

3. Patients unable to participate in the consent process