Inclusion Criteria:
All consents:
- > or = to 18 years of age
- Ability to provide informed consent
Consent 1:
Mesothelioma
- Histologically proven diagnosis of Mesothelioma OR Choroidal nevus
- Diagnosis of choroidal nevus by direct examination and/or ultrasound/optical
coherence tomography and possibly fluorescein angiography OR Primary uveal melanoma
- Diagnosis of uveal melanoma by direct examination and/or ultrasound/optical coherence
tomography and possibly fluorescein angiography
Consent 2:
Mesothelioma
- Histologically proven diagnosis of Mesothelioma AND
- BAP1 mutation or loss of expression identified in tumor sample
OR one of the following:
- Age<50 at diagnosis
- No history of asbestos exposure
- Personal history of choroidal nevus, uveal melanoma, or melanoma
- Family history of choroidal nevus, uveal melanoma, or mesothelioma
- History of malignancy in more than two first-degree relatives OR Choroidal nevus
- Diagnosis of choroidal nevus by direct examination and/or ultrasound/optical
coherence tomography and possibly fluorescein angiography AND one of the following:
- More than one clinical risk factor, which may include: orange pigment, thickness > 1
< 2.5mm
- Personal history of uveal melanoma, skin melanoma, or mesothelioma
- Family history of choroidal nevus, uveal melanoma, or mesothelioma OR Primary uveal
melanoma
- Diagnosis of uveal melanoma by direct examination and/or ultrasound/optical coherence
tomography and possibly fluorescein angiography
AND one of the following:
- Personal history of uveal melanoma, skin melanoma, or mesothelioma
- Family history of choroidal nevus, uveal melanoma, or mesothelioma
- History of malignancy in more than two first-degree relatives OR Metastatic uveal
melanoma
- Histologically proven diagnosis of metastatic uveal melanoma AND
- BAP1 mutation or loss of expression identified in tumor sample
OR one of the following:
- Personal history of uveal melanoma, skin melanoma, or mesothelioma
- Family history of choroidal nevus, uveal melanoma, or mesothelioma
- History of malignancy in more than two first-degree relatives
Consent 3:
- Relative of patient with germline BAP1 mutation identified through identified testing
Exclusion Criteria:
- none