Inclusion Criteria:

- Male or female ≥ 14 - 90 years of age

- Presence of histologically proven NET tumour(s)

- Serum creatinine ≤ 150 µmol/L, and a measured GFR using plasma clearance of ≥50
mL/min

- Haemoglobin concentration 5.5 mmol/L; WBC ≥ 2*109/L; platelets ≥ 100*109/L

- Liver function tests (serum albumin, total bilirubin, ALT, AST and alkaline
phosphatase) ≤ 3X the upper limit of normal

Exclusion Criteria:

- Potential for surgery with curative intent

- Surgery, radiation therapy, cytotoxic chemotherapy, embolization or other
investigative therapy (interferons, mTOR inhibitors) within 12 weeks of enrollment

- Known brain metastases unless these metastases have been treated and stabilized
(confirmed by CT) for ≥ 6 months prior to enrollment

- Uncontrolled congestive heart failure

- Receiving concomitant medications which decrease renal function

- Uncontrolled diabetes mellitus

- Pregnancy