Molecularly Imprinted Polymer Sensors of Modified Nucleosides for Non-invasive Monitoring of Cancer Therapy : the Circadian Rhythms of Urinary Excretion of Modified Nucleosides.
Inclusion Criteria
Inclusion Criteria for patients:
- Histologically-confirmed metastatic colorectal cancer;
- 0 to 3 prior chemotherapy lines;
- Signed informed consent;
- Good understanding of the protocol and of the follow-up;
- Estimated life expectancy exceeding 3 months;
- At least one measurable metastatic lesion (RECIST criteria);
- Performance Status (WHO) of 0 to 2;
- Good haematological, hepatic and renal functions.
Inclusion criteria for healthy subject
- Age ≥ 18 ans
- Signed informed consent;
- Good understanding of the protocol and of the follow-up;
- Good haematological, hepatic and renal functions.
- Test HIV and B and C hepatitis negative test
- No chronic or acute diseases
Exclusion Criteria for patients:
- Poor performance status (>2);
- Poor haematological, hepatic or renal functions;
- Uncontrolled chronic disease;
- Serious unhealed wound, ulcer or fracture within the previous month;
- Clinical or laboratory finding suggesting possible abnormalities in nucleosides
urinary excretion;
- Pregnancy or breast-feeding during the previous month;
- Transmeridian trip of more than 4 time zones within the prior 2 weeks;
- Person with legal restriction to participate into clinical research, according to the
current law in France.
Exclusion criteria for healthy subject:
- Poor haematological, hepatic or renal functions;
- Uncontrolled chronic disease;
- Serious unhealed wound, ulcer or fracture within the previous month;
- Clinical or laboratory finding suggesting possible abnormalities in nucleosides
urinary excretion;
- Pregnancy or breast-feeding during the previous month;
- Transmeridian trip of more than 4 time zones within the prior 2 weeks;
- Person with legal restriction to participate into clinical research, according to the
current law in France.