Inclusion Criteria:

1. Current diagnosis of AK, with ≥4 lesions located in the same anatomical district
(within a contiguous 50 cm2 area on the face, bold scalp or forehead);

2. Female or male >18 years of age;

3. Skin type I or II according to Fitzpatrick;

4. Patient has confirmed his/her willingness to participate in this study;.

Exclusion Criteria:

1. Topical drug therapy for AK within the past 3 months or for photoaging in the last 6
months, or had lesion-directed therapy within 2 cm2 of the selected AK area during
the previous month;

2. Suitable for surgical, photodynamic or any other topical treatment in the next 6
months;

3. Subjects who suffer/ had suffered from skin cancer or show an early stage of skin
cancer or have a genetic predisposition for skin cancer;

4. Other skin disease that requires treatment with other medications in the treatment
area or in the distance of 3 cm;

5. Immunosuppression or current treatment for cancer;

6. Clinically unstable medical condition;

7. High risk group for HIV infection or presentation of other infectious diseases

8. Presentation of contact allergies or allergies to compounds of the test substances;

9. Smoker (more than forty cigarettes per day) or heavy drinker (more than three
standard drinks per day);

10. Psychiatric disease that may interfere with follow up of study procedures;

11. Participation in other clinical trials up to 30 days prior to day 1 of the study

12. Prior treatment with study medication in the area to be treated;

13. Considered by the investigator, for any other reason, to be an unsuitable candidate
for the study.