NUP98/JARID1A as a Recurrent Aberration in Pediatric Acute Megakaryoblastic Leukemia
OBJECTIVES:
- To determine whether NUP98/JARID1A expression is a recurrent translocation in
NUP98-rearranged cases in pediatric acute megakaryoblastic leukemia (AMKL).
- To screen the Children Oncology Group (COG) samples for genetic aberrations in
pediatric AMKL.
OUTLINE: Cryopreserved specimens are analyzed for NUP98 fusion to NSD1, JARID1A, and TOP1,
myeloid/lymphoid or mixed-lineage leukemia (MLL)-rearrangements, and other gene expression
profiling by reverse-transcriptase polymerase chain reaction (RT-PCR) and karyotyping or
fluorescence in situ hybridization ( FISH). Results are then compared with each patient's
outcome data.
Observational
N/A
NUP98/JARID1A as a recurrent aberration in pediatric AMKL
No
Soheil Meshinchi, MD
Principal Investigator
Fred Hutchinson Cancer Research Center
United States: Federal Government
CDR0000736633
NCT01642069
July 2012
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