Inclusion Criteria:

- Histologically proven colorectal adenocarcinoma

- With hepatic metastasis and no evidence of extrahepatic metastasis (the liver
metastases must be determined by a hepatic surgeon to be resectable)

- 20~80 years

- ECOG performance status 0 - 1

- Adequate laboratory findings

Exclusion Criteria:

- Prior chemotherapy for metastatic disease

- Prior adjuvant chemotherapy, if administered within 6 months before study entry

- Previous hepatic-directed therapy including hepatic resection and/or ablation,
hepatic arterial infusion therapy, or hepatic radiation therapy

- Uncontrolled medical illnesses including medically uncontrolled infection,
uncontrolled hypertension, unstable angina, symptomatic congestive heart failure,
myocardial infarction within 6 months

- Chronic active hepatitis or cirrhosis