Inclusion Criteria:

- Aged 18-70 years of age with a diagnosis of a haematological malignancy that requires
an allograft, with a partially HLA mismatched donor (<5/6)

- Adequate organ function, defined as:

- LVEF >/= 45%

- DLCO, FEV1, FVC >/= 50% predicted

- Total bilirubin <35umol/L

- AST/ALT and alkaline phosphatase <5x upper limit of normal

- Serum creatinine within normal range, or if outside normal range for age, then
creatinine clearance >40ml/min/1.73m2

- Karnofsky performance score 60-100

- Donor available aged >/= 18 years

- Needs an urgent transplant where a suitable HLA matched sibling or unrelated donor is
unavailable in a timely manner.

- Donor available who is at least a 5/10 mathch

- Donor and recipient identical at at least one of the following alleles: HLA-A, HLA-B,
HLA-Cw, HLA-DRB1 or HLA-DQB1

- Patient must have received cytotoxic chemotherapy within 3 months of consent date

- Written informed consent

Exclusion Criteria:

- HLA matched, related donor able to donate

- Autologous haematopoietic stem cell transplant <3 months prior to enrolment

- Pregnancy or breastfeeding

- Uncontrolled bacterial, viral or fungal infection

- Serious psychiatric or psychological disorders

- Absence of, or inability to provide, informed consent

- Severe comorbidity (Seattle comorbidity score of 3 or more) or disease that prevents
treatment with chemotherapy

- Positive anti-donor HLA antibody

- Unable to receive 2Gy TBI (RIC pathway) or 12Gy TBI (MAC pathway)

- Patient with graft rejection following a previous allograft from either adult or cord
blood donors