Inclusion Criteria:

- Histologically-confirmed, invasive metastatic breast cancer.

- Estrogen-receptor positivity (defined by at least 5% staining by
immunohistochemistry) on either the primary breast tumor or a metastatic biopsy.

- Postmenopausal status, defined as: either surgical menopause via oophorectomy, or
natural menopause in which the patient has had no menses in the previous 12-month
period. Premenopausal patients who have been been rendered amenorrheic by tamoxifen
must have a serum estradiol level 30 pg/ml after discontinuation of tamoxifen.
Amenorrheic premenopausal subjects must have a negative pregnancy test during
screening (prior to enrollment) and must be advised to use adequate contraception
throughout their participation.

- Prior therapy for the current malignancy: Patient must have 1) relapsed within 2
years of completing adjuvant hormonal therapy with a non-steroidal aromatase
inhibitor, OR 2) failed a non-steroidal aromatase inhibitor in the metastatic
setting. There is no limit to prior chemotherapy or hormonal regimens for this
malignancy.

- Patient must have one measurable lesion by RECIST criteria. Bone-only disease is not
allowed.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

- Adequate organ and bone marrow function

- The subject is capable of understanding and complying with the protocol requirements
and has signed the informed consent document.

Exclusion Criteria:

- Chemotherapy, hormonal therapy or investigational anti-tumor therapy within 21 days
of starting study treatment. Use of bone-building agents is allowed.

- Any type of investigational agent within 28 days before the first dose of study
treatment.

- Unresolved clinically-meaningful toxicity due to prior therapy. Toxicity from
previous treatment must be back to baseline or Grade 1, with the exception of
neurotoxicity and alopecia.

- Untreated or uncontrolled brain metastases or evidence of leptomeningeal involvement
of disease. Patients who have stable disease after radiotherapy for CNS disease are
eligible. Testing for brain involvement in the absence of symptoms is not required as
part of this protocol.

- Uncontrolled, intercurrent illness including, but not limited to:

- Known ongoing or active infection, including active hepatitis B or hepatitis C.
Testing for hepatitis B or C is not required as part of this protocol.

- Uncontrolled diabetes mellitus

- Uncontrolled hypertension

- Symptomatic congestive heart failure, unstable angina pectoris, stroke or myocardial
infarction within 3 months

- A baseline corrected QT interval (QTc) greater than 470 ms.

- The subject is known to be positive for the human immunodeficiency virus (HIV). Note:
baseline HIV screening is not required

- The subject is unable or unwilling to abide by the study protocol or cooperate fully
with the investigator or designee.