Inclusion Criteria:

- 18 years old

- patient suffering breast cancer with mastectomy/tumorectomy with or within cleaning 2
weeks after inclusion with or within pre-emptive chemotherapy

Exclusion Criteria:

- Against-indication at memantine administration : hypersensitivity at active substance
or excipients, hypertension, antecedent cerebrovascular accident, severe cardiac
insufficiency

- Diabetic patient (Type I and II)

- Patient with medical or surgical antecedents

- Patient receiving treatment with amantadine, ketamine, dextrometorphan, L-Dopa,
dopaminergic, anticholinergic agonists, barbiturate, neuroleptic, IMAO, antispastic
agents, dantrolen or baclofen, phenitoin, cimetidine, ranitidine, procainamide,
quinidine, quinine, nicotine, hydrochlorothiazide, warfarine

- Patient with alcohol addiction

- Woman in childbearing age not using effective contraceptive method, pregnant or
lactating woman

- Patient who participated in another clinical trial, located in exclusion period or
received benefits > 4500 euros during 12 months before the beginning of trial