Analysis of MicroRNA Expression in Down Syndrome Acute Myeloid Leukemia and the Transient Myeloproliferative Disorder
OBJECTIVES:
- To compare miRNA expression in distinctive diagnostic groups: transient
myeloproliferative disorder (TMD), Down syndrome (DS) acute megakaryocytic leukemia
(AMkL), non-DS AMkL, and in remission DS samples (representing germline, non-malignant
samples).
OUTLINE: Archived RNA samples are analyzed for mature micro (mi)RNA expression by real-time
RT-PCR. Results are then compared with miRNA expression of non-Down syndrome patients with
acute megakaryocytic leukemia.
Observational
N/A
Gene expression levels between DS AMKL and non-DS AMKL patients
No
Jeffrey Taub, MD
Principal Investigator
Children's Hospital of Michigan
United States: Federal Government
CDR0000722054
NCT01511575
February 2012
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