Effect of Hydroxyethyl Starch on Renal Handling of Salt and Water, Blood Pressure-regulating Hormones, Proteins and Circulatory System of Patients Undergoing Kidney Removal by Keyhole Surgery
Hydroxyethyl starch (HES) is widely used in hospitals to maintain circulation in critically
ill patients. In recent years studies have raised suspicion that HES is nephrotoxic. So far
acute kidney injury has been diagnosed based on creatinine measurements, but new technology
allows for earlier diagnosis using measurements of biomarkers in urine. The purpose of this
project is to investigate HES's potential toxicity and effects on the circulation and
kidneys using measurements of biomarkers specific for toxicity and for the sodium/water
balance in the urine and by measurements of vasoactive hormones in the blood after
administration of HES 130/0.4
Interventional
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
u-NGAL
The main objective for the trial(only patients undergoing elective laparoscopic nephrectomy) is to measure the effect of hydroxyethyl starch on u-NGAL, which is a biomarker of nephrotoxicity
2-4 hours
Yes
Anne Sophie P. Kancir, MD PhD
Principal Investigator
Regional Hospital Holstebro
Denmark: National Board of Health
ASK-1-2011
NCT01486550
December 2011
November 2014
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