Inclusion Criteria:

- Histologically confirmed chemotherapy naïve endometrial cancer

- One of following histology Endometrioid, UPSC, CCCa, squamous, adenosquamous, mixed

- FIGO stage IVb or recurrent endometrial cancer (incurable by surgery and/or RT)

- At least one measurable lesion by RECIST on CT

- ECOG PS: 0-2

- Age: 20-75

- Adequate organ function BM: ANC≥1,000/mm3, Plt≥100X103/mm3 Kidney: Creatinine<1.25 ×
UNL이고, GFR ≥ 60 Liver: AST, ALT< 3×UNL, T- bil<1.5 mg/ mm3

- Informed Consent

- Contraception during study period

Exclusion Criteria:

- Previous chemotherapy

- RT, hormone therapy, or immunotherapy within 1 month

- Other malignant disease

- Uncontrolled medical disease

- Infection requiring antibiotics

- Symptomatic CHF, RF, Angina, Arrhythmia, etc.

- Neurosis or psychosis

- Pregnancy, breast-feeding

- Etc.