Inclusion Criteria:

- Patients with suspected or biopsy-proven, locally advanced rectal cancer will be
eligible for enrollment.

- Patients must be 18 years or older. Patients must not be pregnant and, if of
child-bearing age, must take precautions not to become pregnant.

- No life expectancy restrictions.

- ECOG and Karnofsky Performance Status will not be employed.

- Patients with renal failure are ineligible for this study (GFR must be > 60)

- Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria:

- Patients who have undergone prior treatment for rectal cancer are ineligible for
enrollment.

- No restrictions regarding use of other investigational agents.

- Patients with severe contrast allergy are ineligible.

- Patients who are pregnant or are trying to become pregnant are excluded from this
study.

- Patients who are cancer survivors or HIV-positive will not be excluded.