Inclusion Criteria:

- Type 2 diabetes according ADA

- Less than a year of evolution since diagnosis

- Antihyperglycemic pharmacological treatment

- HbA1c between 7.1% and 9.0%

- Stable weight during the last 6 months

- Body Mass Index ≥ 25 kg/m2 and <35kg/m2.

- Blood pressure ≤ 130/80 mmHg

- Childbearing women under contraceptive treatment

- Signed Informed Consent Form

- Age from 18 to 70 years old

Exclusion Criteria:

- Non-fulfilment treatment in the screening period

- Drugs or alcohol abuse

- Creatinine depuration estimated with MDRD formula using serum creatinine < 90
ml/min/1.72m2

- History of chronic liver disease, ALT or AST ≥ 2 times from the normal superior
limit, or GGT ≥ 3 times from the normal superior limit.

- Chronic lung disease, that causes dyspnea equivalent to a functional class ≥3
(NYHA)or that requires oxygen supplementation.

- History or symptoms of coronary artery disease (CAD) or cerebrovascular disease
(CVD).

- Drug treatment that interact with biguanides.

- Another chronic diseases that restricts survival or associated with chronic
inflammation like: cancer, leukemia, lymphoma, erythematosus lupus, asthma,
rheumatoid arthritis or infection for HIV.

- Pregnancy or positive pregnancy test in women under 50 years old or breastfeeding.