Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma
N/A
20 Years
70 Years
20 Years
70 Years
Open (Enrolling)
Both
Cushing Syndrome
Both
Cushing Syndrome
Trial Information
Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma
Inclusion Criteria:
- patients with both unilateral adrenal incidentaloma and hypercortisolism
- definition of hypercortisolism
- overnight dexamethasone suppression test, serum cortisol>1.8ug/dL
- 24hr urine cortisol > upper reference limit
Exclusion Criteria:
- patients who took medication influencing cortisol secretion
- patients with definite clinical feature of cushing syndrome
- moon face
- abdominal striae
- skin or proximal muscle atrophy
- metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure,
rheumatic disease, hematologic disease
- patients who took following medication
- insulin
- oral hypoglycemic agent
- thyroid hormone
- anti-hyperlipidemic drug
- sex hormone
- patients who taking steroid hormone or who took steroid hormone more than 2 weeks
within 1 year
- psychiatric disease
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Change of lipid profile between two groups
Outcome Description:
lipid profile with LDL,apo B
Outcome Time Frame:
4 Year
Safety Issue:
No
Principal Investigator
Jae Hyeon Kim
Investigator Role:
Study Director
Investigator Affiliation:
Samsung Medical Center
Authority:
South Korea: Institutional Review Board
Study ID:
2011-03-034
NCT ID:
NCT01382420
Start Date:
May 2011
Completion Date:
Related Keywords:
- Cushing Syndrome
- subclinical cushing syndrome
- hypercortisolism
- adrenal incidentaloma
- adrenalectomy
- Cushing Syndrome
- Adrenocortical Adenoma
- Adrenal Gland Neoplasms
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