Inclusion Criteria:

- Patients with confirmed melanoma-patients informed of the aims of the study , the
modalities

- Patients who signed the consent form ou a non opposition form signed by the patient
or by a relative

According to study part:

Part 1: patients with a melanoma larger than 10mm or with cutaneous metastasis Part 2:
stage IV melanoma patients who shall undergo a regional lymph node dissection Part 3:
retrospective study of patients who underwent a sentinel node procedure Part 4: Patients
achieves of inoperable melanomas the stage(stadium) III or IV that must receive in
treatment (processing) a chemotherapy (by the dacarbazine or by the cisplatin or by the
inhibitor of B-raf) and carrier of at least two cutaneous metastases

Exclusion Criteria:

- Refusal to take part in the study (patient or relative)

- Contraindications known to the xylocaine (groups 1,2, and 4)

- No affiliated to the social security system (groups 1, 2, and 4)