Nutrition and Body Composition in Acute Lymphoblastic Leukemia (Environment and Microenvironment in ALL #2)
Inclusion Criteria:
GROUP A: PATIENTS WITH NEWLY DIAGNOSED ALL:
- Are greater than or equal to 10 years of age and less than or equal to 21 years of
age at diagnosis of ALL
- Have a new diagnosis of untreated ALL classified as "high risk" per NCI criteria (due
to being greater than 10 years of age)
- Are beginning treatment with a Children's Cancer Group/Children's Oncology Group
"high risk" protocol with a 4-drug induction including steroids
- Are not pregnant
GROUP B: EARLY SURVIVORS OF ALL
- Were treated for ALL and remain in first complete remission ("CR1")
- Were equal to or greater than 10 years of age and less than or equal to 21 years of
age at diagnosis of ALL
- Have completed treatment on or as per a Children's Cancer Group/Children's Oncology
Group "high risk" protocol between 12 and 48 months prior to enrollment in this study
(consisting of a plan for a 4-drug induction including steroids in Induction, Delayed
Intensification, and steroid pulses in Maintenance. Steroids are allowed to have
been discontinued due to toxicity).
- Are not pregnant
GROUP C: SIBLINGS OF GROUP A
- Are either a full-sibling or a half-sibling of a patient in Group A
- Are living at the same residence as the sibling/half-sibling from Group A
- Are greater than or equal to 10 years of age and less than or equal to 21 years of
age at the time of study entry, and within 3 years of the age diagnosis of ALL in the
sibling/half-sibling from Group A
- Are on the same Vitamin D supplementation regimen (if any) as the sibling from Group
A at the time of his or her diagnosis
Exclusion Criteria (ALL GROUPS):
- Have a diagnosis of Down syndrome (Trisomy 21) or any genetic disease associated with
abnormal bone development
- Are undergoing treatment with other medicines that affect bones including chronic use
of of steroids, bisphosphonate therapy, or Vitamin D at average dose greater than
400IU/day
- Have an underlying diseases altering body structure (i.e. missing a limb, severe
dysmorphism) or severely affecting mobility (i.e. total or hemiparesis)
- Have a history of chemotherapy or radiation for other cancers
- Cannot complete the radiology exams/radiology exams uninterpretable (i.e. people with
a hip replacement or prosthesis)