Inclusion Criteria:

- Aged ≥ 18 and ≤ 65 years.

- ECOG performance status of 0 to 1.

- Life expectancy of more than 3 months.

- Histologically or cytologic confirmed HER2 positive or uncertain advanced breast
cancer that is not curable with available therapies.

- Screening laboratory values within the following parameters:

- ANC: ≥ 1.5 x 109/L

- Platelet count: ≥ 100 x 109/L

- Hemoglobin: ≥ 9.0 g/dL

- Serum albumin: ≥ 2.5 g/dL

- Total bilirubin: ≤ 1.5 x upper limit of normal, ULN

- ALT and AST: ≤ 1.5 x ULN

- Serum creatinine: ≤ 1.0 x ULN

- Creatinie clearnce rate: ≥ 50 mL/min

- Cholesterol≤7.75 mmol/L and triglyceride≤2.5 x ULN

- LVEF: ≥ 50%

- QTcF: < 470 ms

- Recovery from all clinically significant AEs related to prior therapies. Duration
from the latest therapy is more than 6 weeks for nitroso or mitomycin, or more than 4
weeks for operation, radiotherapy, cytotoxic agents or molecular targeting.

- Ability or willingness to swallow tablets, no dysfunction of gastrointestinal
absorption.

- All subjects who are not surgically sterile or postmenopausal must agree and commit
to the use of a reliable method of birth control for the duration of the study and
for 6 months after the last dose of test article. For women of child bearing
potential, a negative urine or serum pregnancy test result before initiating
cipatinib.

- Signed informed consent.

Exclusion Criteria:

- Subjects with third space fluid that can not be controled by drainage or other
methods.

- Steroid treatment for more than 50 days, or in need of long-term use of steroids.

- Subjects with uncontrol hypokalemia and hypomagniesemia before study entry.

- Subjects can not interrupt the using of the drugs that may cause QT prolongation
during study.

- Subjects with meningioma, or with active central nervous system metastases as
indicated by clinical symptoms.

- Subjects with liver metastases which ALT or AST > 1.5 x ULN.

- Treated or treating with EGFR or HER2 TKIs before study entry.

- Receiving any other antitumor therapy.

- Less than 4 weeks from the last clinical trial.

- Pregnant or breastfeeding women.

- Known history of hypersensitivity to cipatinib or any of it components.

- Ongoing infection (determined by investigator).

- Subjects had any heart disease: coronary artery disease, arrhythmia need to treat,
heart failure, LVEF < 50%, and any other heart disease that is determined as unfit
for this study by investigator, etc.

- Evidence of significant medical illness that in the investigator's judgment will
substantially increase the risk associated with the subject's participation in and
completion of the study. Examples include, but are not limited to, hypertension,
severe diabetes, or thyroid disease.

- Known history of neurological or psychiatric disease, including epilepsy or dementia.