PEG-asparaginase Treatment in the NOPHO ALL-2008 Protocol: Antibody Formation, Pharmacokinetics, Pharmacodynamics and Side Effects.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Asparagine depletion
Bloodsamples and cerebrospinalfluidsamples are collected at certain timepoints during 30 weeks of treatment with PEG-asparaginase. They are analysed for asparagine, asparaginase-enzymeactivity and asparaginase-antibodies.These measures tell about the effect of the drug, PEG-asparaginase.
Up to 30 weeks of treatment
No
Louise T Henriksen, MD
Principal Investigator
Aarhus University Hospital
Denmark: The Danish National Committee on Biomedical Research Ethics
LTH-1
NCT01272440
January 2011
December 2012
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