Implication of the Antiapoptotic Protein BCL-B in the Pathogenesis of Multiple Myeloma
Observational
Observational Model: Cohort, Time Perspective: Prospective
To determine whether BCL-B is a survival factor in malignant plasmocytes, we will analyse the level of expression of Bcl-B at the both mRNA and protein levels in a cohort of MGUS and MM patients.
To determine whether BCL-B is a survival factor in malignant plasmocytes,we will analyse the level of expression of Bcl-B at the both mRNA and protein levels in a cohort of MGUS and MM patients. The implication of Bcl-B in malignant plasmocyte survival will be evaluated by loss of fucntion experiments (Si-RNA). This will also allow to determine whether Bcl-B is involved in the MGUS to MM transition.
6 months
No
Jean-Gabriel FUZIBET, MD
Principal Investigator
CHU de Nice Service de Médecine Interne et Cancérologie Hôpital de l'Archet
France: French Data Protection Authority
09-PP-10
NCT01270009
November 2010
November 2013
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