Inclusion Criteria:

- Histologic proof of primary squamous cell or adenocarcinoma of the esophagus

- Locoregionally advanced carcinoma of esophagus without systemic metastases

- Zubrod Performance Status 0-1;

- Patients ≥ 18 years of age;

- No hypersensitivity to E. coli −derived products;

- AGC ≥ 1500/mm3, platelets ≥ 150,000/mm3, Hgb ≥ 10 gm%, serum creatinine ≤ 1.5 mg/dl
and/or calculated creatinine clearance ≥ 65 cc/min; serum calcium ≤ 11gm/dl;

- Patients with prior malignancy are eligible if curable non-melanoma skin cancer or
cervical cancer in situ or disease free ≥ 5 years;

- No prior chest or upper abdomen radiotherapy; no prior systemic chemotherapy within
the past 5 years; no prior esophageal or gastric surgery;

- Written informed consent.

Exclusion Criteria:

- Evidence of tracheoesophageal fistula, or invasion into the trachea or major bronchi.

- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
for a minimum of 2 years (For example, carcinoma in situ of the breast, oral cavity,
or cervix are all permissible).

- Prior systemic chemotherapy or radiation therapy for esophageal cancer