Phase 3 Study of 30Gy Versus 40Gy Involved-field Radiotherapy in Localized Diffuse Large B Cell Lymphoma Achieving CR After Chemotherapy
The best proper doses of IFRT in combined modality treatments (CMT) for localized DLBCL is
still undetermined. Existing treatment guidelines recommend 40Gy or above as the standard
treatment dosage. However, there were large-scaled clinical trials implying smaller doses
such as 30Gy may be equivalent effective. Lowering radiation doses can decrease treatment
toxicities and radiotherapy-induced diseases, which has been conformed by HD13 study for
Hodgkin's Lymphoma. It may even retain the truth when modern era radiation techniques are
involved and especially in patients achieving CR after chemotherapy. A comprehensive,
prospective dose-comparing study is needed.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
disease free survival
five years
No
Yexiong Li, MD
Study Director
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
China: Federal Institute for Drugs and Medical Devices
CH-LYM-004
NCT01156259
April 2010
May 2015
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