Identification of Biomarkers Predicting Responsiveness to Rituximab in Follicular Lymphoma
OBJECTIVES:
- Correlate immunoglobulin Fc receptor (FcγR) polymorphisms with response, response
duration, and time to resistance in samples from patients with follicular lymphoma (FL)
treated with single-agent rituximab on ECOG-E4402.
- Identify gene expression profiles that correlate with response, response duration, and
time to rituximab resistance in these patients.
- Determine whether the FL microenvironment is predictive of initial response and
duration of response to rituximab.
OUTLINE: DNA and RNA from banked peripheral blood mononuclear cells (PBMCs) and
formalin-fixed paraffin-embedded (FFPE) tumor samples are analyzed for
immunoglobulin-receptor polymorphism, gene expression profile, and follicular lymphoma
microenvironment by real-time PCR, microarray hybridization, and IHC.
PROJECTED ACCRUAL: A total of 259 PBMC samples and 300 FFPE blocks will be accrued for this
study.
Observational
N/A
Correlation between FcγR polymorphisms and rituximab response, response duration, and time to resistance
No
Brad S. Kahl, MD
Principal Investigator
University of Wisconsin, Madison
Unspecified
CDR0000675681
NCT01150643
August 2010
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