A Randomized Phase III Trial for Timing of Radiation in Concurrent Chemoradiation for Limited Stage Small-cell Lung Cancer
Inclusion Criteria:
- histologically confirmed small-cell lung cancer
- limited disease status
- with evaluable disease
- 18 years or older
- ECOG performance status 0,1,2
- expected survival time should be 12 weeks or longer
- Adequate organ function as evidenced by the following; Absolute neutrophil count >
1.5 x 109/L; platelets > 100 x 109/L; total bilirubin ≤1.5 UNL; AST and/or ALT < 5
UNL; creatinine clearance ≥ 50mL/min
- Written informed consent form
Exclusion Criteria:
1. Uncontrolled systemic illness such as DM, CHF, unstable angina, hypertension or
arrhythmia
2. Patients with active infection requiring antibiotics
3. Pregnant or nursing women ( Women of reproductive potential have to agree to use an
effective contraceptive method)
4. Prior history of malignancy within 5 years from study entry except for a adequately
treated basal cell or squamous cell skin cancer or in situ cervical cancer,
well-treated thyroid cancer
5. previous history of chemotherapy or radiotherapy