Randomized, Placebo-controlled Trial of Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis in Patients Receiving High Dose Cisplatin in Routine Medical Practice
Ondansetron plus dexamethasone are standard emetic prophylactic agents for highly emetogenic
chemotherapy. Metoclopramide is a dopamine antagonist, which may enhance efficacy of
ondansetron and dexamethasone.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Number of Patients Who Had Complete Response
number of patients who experience no emesis and need no rescue treatment in 5-day period
5 days after receiving chemotherapy
No
Suthinee Ithimakin, MD
Principal Investigator
Faculty of medicine Siriraj Hospital
Thailand: Ethical Committee
Si094/2009
NCT01093690
April 2009
October 2010
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