Understanding the Role of Meat-Borne Carcinogen in Pancreatic Cancer Etiology
Pancreatic cancer is rapidly fatal in most cases and little is known about its causes.
Identifying and modifying risk factors can reduce mortality through prevention. Carcinogens
that form in meat cooked at high temperatures may be modifiable risk factors for pancreatic
cancer, but direct evidence is needed to demonstrate involvement in pancreas tissue. We
propose to recruit subjects scheduled for pancreatectomy as a treatment for pancreatic
cancer. These subjects will ingest a very low dose of radiolabeled PhIP, a meat-derived
carcinogen, and a small amount of resected tissue (waste) will be analyzed with highly
sensitive technology to determine if this carcinogen binds to DNA in the pancreas. We
hypothesize that the meat-derived carcinogen will bind to DNA in the pancreas. The amount of
PhIP ingested is equivalent to the amount in two very well-done barbecued chicken breasts
and the dose of radioactivity is comparable to a typical chest x-ray. This research can
increase understanding of pancreatic carcinogenesis, facilitating the design of prevention
strategies.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Quantify and characterize HCA-DNA adducts in resected human pancreatic tissue after a dietary relevant dose of PhIP, the most mass abundant HCA in charred meat.
6 hours post ingestion
No
Kristin E Anderson, PhD
Principal Investigator
University of Minnesota - Clinical and Translational Science Institute
United States: Food and Drug Administration
0712M23122
NCT01092689
January 2012
December 2012
Name | Location |
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University of Minnesota | Minneapolis, Minnesota 55455 |