Large Scale Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From Monoclonal Gammopathy of Undetermined Significance (MGUS) and Indolent Myeloma (SMM).
Inclusion Criteria:
- Patients aged from 18 to 70 years
- Written informed consent
- One of the following three criteria:
- Recently diagnosed IgG or IgA monoclonal gammopathy without clinical or
biological features of malignant hemopathy
- IgG or IgA MGUS regardless the date of the diagnosis
- SMM regardless the date of the diagnosis
- Normal blood count, creatininemia and calcemia *
- Bence-Jones proteinuria below 1g/24 hours
- Absence of bone pain
- No clinical or biological features of amyloidosis
- No recurrent episode of infection (more than 2 infections requiring antibiotics in
the previous 6 months) * In case of abnormal blood count, renal failure or
hypercalcemia, patients may be included if an intercurrent cause is identified (for
example anemia associated with iron deficiency)
Diagnostic criteria for MGUS:
- Monoclonal component concentration below 30 g / l AND
- Bone marrow plasmacytosis below 10%
- Bence-Jones proteinuria below 1g/24 hours
- Normal blood count, creatininemia and calcemia *
- Absence of bone lesions on conventional bone radiographies
- No clinical or biological features of amyloidosis
- Absence of hyperviscosity syndrome
- No recurrent episode of infection (more than 2 infections requiring antibiotics in
the previous 6 months) * In case of abnormal blood count, renal failure or
hypercalcemia, patients may be included if an intercurrent cause is identified (for
example anemia associated with iron deficiency)
Diagnostic criteria for SMM:
- Monoclonal component concentration greater than 30 g / l AND / OR
- Bone marrow plasmacytosis greater than 10%
- Bence-Jones proteinuria below 1g/24 hours
- Normal blood count, creatininemia and calcemia *
- Absence of bone lesions on conventional bone radiographies
- No clinical or biological features of amyloidosis
- Absence of hyperviscosity syndrome
- No recurrent episode of infection (more than 2 infections requiring antibiotics in
the previous 6 months) * In case of abnormal blood count, renal failure or
hypercalcemia, patients may be included if an intercurrent cause is identified (for
example anemia associated with iron deficiency)
Exclusion Criteria:
- Patients younger than 18 years
- Patients older than 71 years
- IgM monoclonal gammopathy (regardless of diagnosis)
- Monoclonal gammopathy associated with hematologic malignancies (multiple myeloma,
chronic lymphocytic leukemia, ...)
- Patients with chronic liver disease, autoimmune or neoplastic disease for less than 5
years
- Active viral hepatitis B or C
- HIV seropositive patient
- Pregnant woman
- Breastfeeding woman