Inclusion Criteria:

Patients must have histologically confirmed metastatic or unresectable renal cell
carcinoma Renal carcinoma patients with predominant clear-cell histology are eligible;
papillary renal cell carcinoma, oncocytoma, collecting duct tumors and transitional cell
carcinoma are NOT eligible No prior systemic treatments for metastatic disease are
permitted, including antiangiogenic therapy, immunotherapy, chemotherapy and
investigational therapy Prior palliative radiation to metastatic lesion(s) is permitted,
provided there is at least one measurable and/or evaluable lesion(s) that has not been
irradiated Radiation therapy must be completed > 4 weeks prior to registration Patients
must have measurable disease, defined as at least one lesion that can be accurately
measured in at least one dimension as >= 20 mm with conventional techniques or as
approximately >= 10 mm with spiral computed tomography (CT) scan (Response Evaluation
Criteria in Solid Tumors [RECIST] 1.0 criteria) Eastern Cooperative Oncology Group (ECOG)
performance status =< 2 Leukocytes > 3,000/mm^3 Absolute neutrophil count > 1,500/mm^3
Platelets > 100,000/mm^3 Total bilirubin < 1.5 x laboratory upper limit of normal (ULN)
Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase [SGOT])/ alanine
transaminase (ALT)(serum glutamic pyruvic transaminase [SGPT]) < 2.5 x laboratory ULN
Creatinine < 1.5 x laboratory ULN Prothrombin time (PT)/international normalized ratio
(INR) < 1.5 Urine protein < 1+; if > 1+, 24 hour urine protein should be obtained and
should be < 1000 mg Women of child-bearing potential must agree to use adequate
contraception (hormonal or barrier method of birth control; abstinence) prior to study
entry and for the duration of study participation Should a woman become pregnant or
suspect she is pregnant while participating in this study, she should inform her treating
physician immediately Ability to understand and the willingness to sign a written informed
consent document Except for Dalteparin that will be administered as a study drug, the
patients should not take any other anticoagulants or antiplatelet agents during the study,
including but not limited to nonsteroidal anti-inflammatory drugs (NSAID) (any dose of
aspirin), warfarin or other anticoagulants

Exclusion Criteria:

Prior therapy with Sunitinib Patients may not be receiving any other investigational
agents Patients with known central nervous system (CNS) metastases; patients should have a
head CT/magnetic resonance imaging (MRI) within 4 weeks prior to treatment initiation; any
imaging abnormality indicative of CNS metastases will exclude the patient from the study
Patients with a "currently active" second malignancy other than non-melanoma skin cancers
are not eligible; patients are not considered to have a "currently active" malignancy if
they have completed anti-cancer therapy and are considered by their physician to be at
less than 30% risk of relapse Patients with a large (> 2 cm) pulmonary lesion involving
the trachea or one of the main bronchus and any endobronchial lesion History of allergic
reactions attributed to compounds of similar chemical or biologic composition to
dalteparin Evidence of bleeding diathesis within last 6 months Serious or non-healing
wound, ulcer or bone fracture or active peptic ulceration Uncontrolled intercurrent
illness including, but not limited to, ongoing or active infection, symptomatic congestive
heart failure (New York Association Class II, III, or IV), angina pectoris requiring
nitrate therapy, recent myocardial infarction (< the last 6 months), cardiac arrhythmia,
history of cerebrovascular accident (CVA) within 6 months (thrombotic or hemorrhagic),
hypertension (defined as blood pressure of > 160 mmHg systolic and/or > 90 mm Hg diastolic
on medication), hemorrhagic retinopathy, history of peripheral vascular disease, or
psychiatric illness/social situations that would limit compliance with study requirements
Patients with an ejection fraction < 50% by multi gated acquisition scan (MUGA) scan are
not eligible Pregnant women are excluded from this study because sunitinib is an
angiogenesis inhibitor agent with the potential for teratogenic or abortion inducing
effects History of abdominal fistula, gastrointestinal perforation or intra-abdominal
abscess within 28 days prior to day 1 therapy

Invasive procedures defined as:

- Major surgical procedure, open biopsy, or significant traumatic injury within 6 weeks
prior to day 1 therapy

- Anticipation of need for major surgical procedures during the course of the study

- Core biopsy within 7 days prior to start therapy