A Randomized Phase II Study Preoperative Chemotherapy Versus Preoperative Concurrent Chemoradiotherapy for Patients With Locally Advanced Non-Small Cell Lung Cancer
Management of locally advanced non-small cell lung cancer (NSCLC) remains a challenge. Both
local relapses and distant metastases are frequent, with 5-year survival of 3-17% for
inoperable disease. Staging has historically subdivided stage III disease into clinical
stage IIIA, thought to be potentially amenable to surgery, and stage IIIB, treated by defi
nitive radiotherapy or radiochemotherapy. This phase II trial is to compare neoadjuvant
chemotherapy with concurrent chemoradiotherapy in patients with locally advanced NSCLC to
address optimal induction strategy.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
To estimate the time to recurrence
Every 3 months
No
Jianxing He, MD, FACS
Principal Investigator
The First Affiliated Hospital of Guangzhou Medical University
China: Food and Drug Administration
FAHG20070218
NCT01054482
February 2007
December 2011
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