A Phase II Study With One-cycle Weekly TP-HDFL Followed by Twice Weekly TP-CCRT and Esophagectomy for Locally Advanced Esophageal Cancer
We hypothesize that one-cycle induction chemotherapy may also help to identify
chemo-responsive esophageal cancer patients who are highly treatable by definitive CCRT.in
order to test this hypothesis, we thus propose this phase II clinical study to verify the
role of "response to one-cycle induction chemotherapy"in the prediction of pathologic
complete response rate to CCRT and tje outcomes for patients with loco-regional esophageal
cancer.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To determine whether clinical response to one cycle of induction chemotherapy (TP-HDFL) could predict the pathologic complete response to preoperative chemoradiotherapy (TP-CCRT
2 years
No
Chih-Hung Hsu, M.D
Principal Investigator
National Taiwan University Hospita
Taiwan: Department of Health
200707051M
NCT01034332
December 2007
December 2009
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