Inclusion Criteria:

- Patients with histologically confirmed adenocarcinoma of the colon or rectum

- Unresectable metastases

- At least one bidimensionally measurable lesion of ≥ 1 cm

- No previous chemotherapy for metastatic disease; Completed at least more than 1 year
oxaliplatin therapy for adjuvant treatment

- 18-75 years old

- ECOG 0-2

- Life expectancy greater than 3 months

- Hemogram: WBC≥4.0 X109/L, ANC ≥2 X109/L, PLT ≥100 X109/L, Hb ≥90g/L,

- Adequate Renal Function

- Adequate Liver Function

- Signed informed consent before the treatment

Exclusion Criteria:

- Patients with previous oxaliplatin based adjuvant chemotherapy within 1 Year

- Completely or partially bowel obstruction

- Presence of peripheral neuropathy (CTC＞grade I)

- Severe mental disorder

- CNS metastasis

- With other severe disease: uncontrolled active infectious disease, uncontrolled
hypertension, heart infarction within 1 year, uncontrolled high-risk arrhythmia,
unstable angina

- With other malignant disease previously or concurrently

- Receive other anti-tumor treatment

- Pregnant or lactating women, or women of child bearing potential without
contraceptive method.