Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Local Advanced Gastric Cancer
Inclusion Criteria:
DISEASE CHARACTERISTICS
- Histologically confirmed primary adenocarcinoma of the stomach
- 3-4weeks after radical operation for gastric cancer
- Stage of the gastric cancer was T3-4NxM0
PATIENT CHARACTERISTICS:
- Age: 18 - 70years old
Life expectancy:
- Longer than 3 months
Hematopoietic:
- Granulocyte count at least 1,500/mm3
- Platelet count at least 100,000/mm3
- Hemoglobin at least 80*10^12/mm3
Hepatic:
- AST no greater than 2.5 times ULN
Renal:
- Creatinine no greater than 1.5 times ULN
Other:
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- Prior chemotherapy and radiotherapy were not allowed
- No other concurrent chemotherapy
Radiotherapy:
- Locally radiotherapy for local disease of advanced gastric cancer during adjuvant
treatment was allowed
Surgery:
- See Disease Characteristics
- Prior surgery for gastric cancer was necessary
Exclusion Criteria:
- Haven't recovery from operation or complication of operation
- With the following risk factors: Uncontrolled or severe cardiovascular disease (e.g.,
myocardial infarction within the past 6 months, congestive heart failure treated with
medications, or uncontrolled hypertension)
- Pregnant or nursing
- Other currently active malignancy except nonmelanoma skin cancer
- Uncontrolled or severe bleeding,diarrhea,intestinal obstruction,adhesion of intestine
- metastasis before enrollment
- Received other chemotherapy or radiotherapy after operation