Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)
Patients will be randomized to curcumin (2 curcumin pills twice a day for 12 months) or
placebo (2 pills twice a day for 12 months). Besides, blood samples, risk factor
questionnaire,and biopsies (upper endoscopy and sigmoidoscopy) will be obtained.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
To determine in a randomized, double-blinded, placebo-controlled study the tolerability and efficacy of curcumin to regress intestinal adenomas by measuring duodenal and colorectal/ileal polyp number, and polyp size in patients with FAP.
5 years
No
Marcia R. Cruz-Correa, MD. PhD
Principal Investigator
University of Puerto Rico
United States: Food and Drug Administration
Protocol A2210108-UPR
NCT00927485
November 2007
November 2016
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