VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK]
16 Years
N/A
Both
Sarcoma
Trial Information
VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK]
OBJECTIVES:
- Determine early in the course of treatment which patients treated on clinical trial
CRUK-VORTEX have an increased likelihood of distant metastases so as to highlight
individuals who might benefit from early adjuvant systemic therapy.
OUTLINE: This is a multicenter study.
Tumour and normal tissue samples will be taken at the time of surgery during treatment on
clinical trial CRUK-VORTEXand preserved for future microarray analyses. Tissue microarrays
will be produced from both tumor and normal tissues. Blood samples will be collected for
future DNA analysis.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed soft tissue sarcoma
- Receiving treatment on clinical trial CRUK-VORTEX
- Underwent surgery to remove the tumor no more than 3 months ago
PATIENT CHARACTERISTICS:
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 3 months after
completion of study treatment
- No other major medical illness that would preclude study treatment
- No other prior or concurrent malignancy except adequately treated nonmelanoma
carcinoma of the skin or in situ carcinoma of the cervix
PRIOR CONCURRENT THERAPY:
- No prior radiotherapy to the local site
- No prior neoadjuvant or adjuvant chemotherapy
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Increased likelihood of distant metastases
Safety Issue:
No
Principal Investigator
Catherine West
Investigator Role:
Study Chair
Investigator Affiliation:
Christie Hospital NHS Foundation Trust
Authority:
Unspecified
Study ID:
CDR0000581165
NCT ID:
NCT00900211
Start Date:
August 2007
Completion Date:
Related Keywords:
- Sarcoma
- recurrent adult soft tissue sarcoma
- stage I adult soft tissue sarcoma
- stage II adult soft tissue sarcoma
- stage III adult soft tissue sarcoma
- adult synovial sarcoma
- adult angiosarcoma
- adult epithelioid sarcoma
- adult extraskeletal chondrosarcoma
- adult leiomyosarcoma
- adult liposarcoma
- adult malignant fibrous histiocytoma
- adult malignant hemangiopericytoma
- adult malignant mesenchymoma
- adult fibrosarcoma
- adult neurofibrosarcoma
- Sarcoma
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