Molecular Markers in Native American Women With Breast Cancer
OBJECTIVES:
- Evaluate a selected panel of molecular markers in tissue specimens from Native American
women with breast cancer.
- Determine which molecular markers provide independent prognostic information with
respect to traditional prognostic factors in these patients.
- Compare and contrast the prevalence of positivity in Native American women with breast
cancer with an age- and stage-matched cohort of Caucasian women with breast cancer
enrolled on clinical trial NCCTG-77-30-51 or the Mayo Breast Cancer Registry.
OUTLINE: Immunohistochemistry is performed on tumor samples to analyze the following
molecular markers: estrogen receptor, progesterone receptor, c-erbB2, p53, Ki-67, Bcl-2,
Bax, cyclin D-1, and insulin-like growth factor-1R.
PROJECTED ACCRUAL: A total of 300 tissue samples (150 from Native American women and 150
from Caucasian women) will be accrued for this study.
Observational
N/A
Evaluation of a selected panel of molecular markers in tissue specimens from Native American women with breast cancer
No
Judith S. Kaur, MD
Study Chair
Mayo Clinic
United States: Federal Government
CDR0000078596
NCT00898976
August 1998
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