Know Cancer

or
forgot password

Evaluation of the Association Between DNA Methylation and Shortened Survival in Patients With Advanced Colorectal Cancer Treated With 5-FU/Oxaliplatin-Based Regimens in E3200


N/A
18 Years
N/A
Not Enrolling
Both
Colorectal Cancer

Thank you

Trial Information

Evaluation of the Association Between DNA Methylation and Shortened Survival in Patients With Advanced Colorectal Cancer Treated With 5-FU/Oxaliplatin-Based Regimens in E3200


OBJECTIVES:

- Determine the CpG island methylation pathway markers that are adverse for survival
after treatment with fluorouracil in patients with advanced colorectal adenocarcinoma
treated with fluorouracil and oxaliplatin with or without bevacizumab on clinical trial
E-3200.

- Compare the methylation results to clinicopathologic and molecular findings and
survival.

OUTLINE: This is a multicenter study.

Tissue, blood, and urine samples and genomic DNA samples from tumor tissue blocks are
examined by pyrosequencing assay for methylation. Genes examined include MINT1, MINT31, P14,
and P16. Microsatellite instability and loss of heterozygosity (LOH) on chromosome 18 (18q
LOH) are also assessed. Microsatellites examined include BAT loci, TGFβRII, D2S123, D55346,
and D17S250.

PROJECTED ACCRUAL: A total of 350 specimens will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of adenocarcinoma of the colon or rectum

- Advanced disease

- Enrolled on clinical trial E-3200 and received fluorouracil and oxaliplatin

- Tumor tissue blocks available

- Routine pathology specimens (i.e., blood, urine) available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Progression-free survival

Safety Issue:

No

Principal Investigator

Stanley Hamilton, MD

Investigator Role:

Study Chair

Investigator Affiliation:

M.D. Anderson Cancer Center

Authority:

Unspecified

Study ID:

CDR0000534281

NCT ID:

NCT00897819

Start Date:

Completion Date:

Related Keywords:

  • Colorectal Cancer
  • recurrent colon cancer
  • recurrent rectal cancer
  • stage III colon cancer
  • stage III rectal cancer
  • stage IV colon cancer
  • stage IV rectal cancer
  • adenocarcinoma of the colon
  • adenocarcinoma of the rectum
  • Colorectal Neoplasms

Name

Location