Low-Intermediate Risk Prostate Cancer: Improving Acute Toxicity Outcomes of Radiotherapy With the Integration of Advanced Imaging for Treatment Planning and Guidance
Advances in medical imaging, and their integration in the treatment planning and daily
guidance of radiotherapy, stand to improve the therapeutic ratio. Improved imaging can
reduce uncertainties by 1) improving the accuracy and reproducibility of organ or tumor
delineation, and 2) guiding and adapting delivery to account for organ motion. This paradigm
has been widely accepted in the radiotherapy community, and much research has addressed the
technical and dosimetric aspects for a sound clinical implementation. However, direct
evidence of a clinical translation to improved patient outcomes is limited. In this study,
we hypothesize that the integration of advanced imaging for treatment planning and guidance
will safely enable a reduction of dose delivered to normal tissues, and will improve
toxicity and quality of life (QOL) outcomes in patients receiving external beam radiotherapy
for low or intermediate risk prostate cancer.
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
To determine whether reducing the dose to normal tissues, enabled by the integration of advanced imaging, reduces the incidence of RTOG/CTC Grade ≥ 2 toxicity.
10 years
No
Cynthia Ménard, MD
Principal Investigator
University Health Network, Toronto
Canada: Ethics Review Committee
UHN REB 06-0520-C
NCT00890006
September 2006
September 2014
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