A Phase II Study of Pemetrexed Plus Carboplatin Combined With Radiation in Patients With Inoperable Locally Advanced Non-small Cell Lung Cancer
Inclusion Criteria:
- Histologically proven non-small cell lung cancer (non-squamous cell carcinoma)
- Presence of measurable disease by RECIST
- Inoperable stage IIIA or IIIB
- ECOG performance status 0-1
- No prior chemotherapy, radiation therapy to chest, immunotherapy, or biologic therapy
- Patients must sign an informed consent indicating that they are aware of the
investigational nature of the study in keeping with the policy of the hospital.
Exclusion Criteria:
- Carcinoid tumor, small cell carcinoma of lung
- Patients with any distant metastasis
- History of another malignancy within the last five years except cured basal cell
carcinoma of skin and cured carcinoma in-situ of uterine cervix Any other morbidity
or situation with contraindication for chemotherapy (e.g. active infection,
myocardial infarction preceding 6 months, symptomatic heart disease including
unstable angina, congestive heart failure or uncontrolled arrhythmias,
immunosuppressive treatment)
- Pregnant or lactating women, women who has not taken test of pregnancy (within 14
days before the first administration) and pregnant women
- Women and men of childbearing potential who have no willing of employing adequate
contraception