Inclusion Criteria:

- Histologically or cytologically documented diagnosis of NSCLC that is
advanced/metastatic (Stage IIIB/IV).

- Performance Status (ECOG) 0-2

- Previous chemotherapy with the exception of dasatinib. Patients who have had any type
of previous chemotherapy regimens for non-small cell lung cancer are eligible.

- Adequate Organ Function:

- Total bilirubin < 2.0 times the institutional Upper Limit of Normal (ULN)

- Hepatic enzymes (AST, ALT ) ≤ 2.5 times the institutional ULN

- Serum Na, K+, Mg2+, Phosphate and Ca2+≥ Lower Limit of Normal (LLN)

- Serum Creatinine < 1.5 time the institutional ULN

- Hemoglobin, Neutrophil count, Platelets, prothrombin time (PT), partial
thromboplastin time (PTT) all Grade 0-1

- Ability to take oral medication

- Concomitant Medications:

- Agree to discontinue St. Johns Wort while receiving dasatinib therapy

- Agree that IV bisphosphonates will be withheld for the first 8 weeks of
dasatinib therapy due to risk of hypocalcemia.

- Women of childbearing potential (WOCBP):

- A negative serum or urine pregnancy test within 72 hours prior to the start of
study drug administration

- Persons of reproductive potential must agree to use and utilize an adequate
method of contraception throughout treatment and for at least 4 weeks after
study drug is stopped Prior to study enrollment.

- Signed written informed consent including a HIPAA form according to institutional
Guidelines

Exclusion Criteria:

- No malignancy [other than the one treated in this study] which required radiotherapy
or systemic treatment within the past 5 years.

- Prior dasatinib therapy.

- Concurrent medical condition which may increase the risk of toxicity, including:

- Patients with severe pulmonary disease that increases the risk of toxicity
related to dasatinib-induced pleural effusions. This includes chronic
obstructive pulmonary disease or pleural effusions (malignant or benign)
requiring chronic oxygen therapy or patients that have had prior pneumonectomy.
Patients that have a pulmonary embolism and require oxygen therapy will be
excluded but not those patients who have a pulmonary embolism but do not require
oxygen therapy. Patients with active pleural effusions not controlled with
pleurodesis will be excluded.

- Cardiac Symptoms; any of the following should be considered for exclusion:

- Uncontrolled angina, congestive heart failure or MI within (6 months)

- Diagnosed congenital long QT syndrome

- Any history of clinically significant ventricular arrhythmias (such as
ventricular tachycardia, ventricular fibrillation, or Torsades de pointes)

- Prolonged QTc interval on pre-entry electrocardiogram (> 450 msec)

- Patients with hypokalemia or hypomagnesemia if it cannot be corrected prior to
dasatinib administration

- History of significant bleeding disorder unrelated to cancer, including:

- Diagnosed congenital bleeding disorders

- Diagnosed acquired bleeding disorder within one year

- Ongoing or recent (≤ 3 months) significant gastrointestinal bleeding

- Concomitant Medications, any of the following should be considered for exclusion:

- Category I drugs that are generally accepted to have a risk of causing Torsades
de Pointes including: (Patients must discontinue drug 7 days prior to starting
dasatinib)

1. quinidine, procainamide, disopyramide

2. amiodarone, sotalol, ibutilide, dofetilide

3. erythromycin, clarithromycin

4. chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide

5. cisapride, bepridil, droperidol, methadone, arsenic, chloroquine,
domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin,
lidoflazine.

- Women:

- unwilling or unable to use an acceptable method to avoid pregnancy for the
entire study period and for at least 4 weeks after cessation of study drug,or

- have a positive pregnancy test at baseline

- pregnant or breastfeeding

- Prisoners or persons who are compulsorily detained (involuntarily incarcerated)for
treatment of either a psychiatric or physical (e.g., infectious) illness

- Patients on systemic anticoagulation at risk of bleeding related to tumor biopsy that
cannot be off anticoagulation per the discretion of their physician.