Inclusion Criteria:

- Subjects between 50 and 75 years old without history of previous SCC or BCC.

- Fitzpatrick skin types I-IV.

- Willing and able to understand and sign informed consent.

- Able to complete study and comply with study procedures

Exclusion Criteria:

- Regular ingestion of supplements containing carotenoids or vitamin A in the past 4
weeks.

- Use of topical retinoids in the past 4 weeks.

- Treatment with systemic retinoids in the past 6 months.

- Dermatologic conditions that require the use of interfering topical or systemic
therapy or that might interfere with study assessments such as, but not limited to,
palmar psoriasis, hand dermatitis or palmo-plantar keratoderma.

- Previous history of psoriasis.

- Clinically significant abnormal findings or conditions, which might, in the opinion
of the Principal Investigator, interfere with study evaluations or pose a risk to
subject safety during the study.

- Subjects who are known to be pregnant or planning a pregnancy.