Gemcitabine vs Gemcitabine + Cisplatin in the Treatment of Advanced Pancreatic Cancer (Stage II III IV)
Inclusion Criteria:
- Histologic or cytologic diagnosis pancreatic cancer
- inoperable stage II or stage III or IV disease(UICC, 1997)
- Age 18 to 75 years
- Karnofsky Performance status > 50
- Signed informed consent
Exclusion Criteria:
- Previous chemotherapy
- Cerebral metastases
- Previous malignancies in past 5 years excluding adequately treated basal or
spinocellular skin cancers and insitu cervical cancer
- Leukocytes < 4000 or neutrophils < 2000 or platelets < 100000 or hemoglobin < 10 g/dl
- Creatinine value > upper normal limit
- GOT or GPT > 2.5 times upper normal limit or bilirubin > 1.5 times upper normal limit
in absence of hepatic metastases
- Congestive heart failure, severe cardiac arrhythmias or coronary ischemic disease
- Other concurrent disease that would, in the investigator's opinion, contraindicate
the use of the study drugs
- Inability to provide informed consent
- Inability to comply with follow-up.