Trial Information

Participation to Colorectal Cancer Screening With Faecal Occult Blood Test and Colonoscopy: an Italian, Multicenter, Randomized Population Study

A nationwide, population-based, multicenter, randomized trial comparing attendance to TC
with that to FOBT was performed. Sixty-four general practitioners (GPs), overall including
in their lists 9,889 average-risk subjects aged 55-64 years, were randomized between TC and
FOBT screening programs. Eligible subjects were mailed a personal invitation letter
co-signed by their GP and the coordinator of the area-reference GI centre. Attendance rate
and detection rate for advanced neoplasia (colorectal cancer, adenoma >10 mm or with villous
histology or high-grade dysplasia) for each arm of the study were assessed.