Inclusion Criteria:

- Age 18+

- Incurable cancer

- Life expectancy three months or longer

- NRS ≥ 4

- Neuropathic pain

- Adequate renal function with cockroft ≥ 60 ml/min

- Signed informed consent

- Expected adequacy of follow up

Exclusion Criteria:

- Previous use of TAD or AED for neuropathic pain within 30 days prior to screening

- Unstable regime of analgetica for 1 week prior to screening

- Use of cannabis

- Radiotherapy aimed at the source of the neuropathic pain 2 weeks before screening

- Chemotherapy with known neurotoxic effect (taxanes, thalidomide, vinca alkaloids,
cytarabine,fluoropyrimidines, oxaliplatin) 2 weeks before screening

- Unstable regime of corticosteroids for 1 week prior to screening

- Pregnancy

- Any condition preventing the intake or absorption of oral drugs

- Participation in any other studies involving investigational products within the 30
days prior to screening