Intra-Operative Dural Brachytherapy With Yttrium-90 Plaque Applicators
- The surgeon will remove the participants tumor from the outer layer of the spinal cord
(dura). The Y-90 applicator and a "dummy" applicator will be brought to the surgery
table in a protected container. A "dummy" applicator is the same size and shape as the
Y-90 plaque applicator but does not contain radioactive plaque. The "dummy" applicator
will be placed on the participants dura to make sure it fits properly, then it will be
removed. The working Y-90 applicator will be placed on the dura for 10-17 1/2 minutes
and then be removed.
- External beam irradiation is a type of high-energy radiation used to kill cancer cells
and shrink tumors. This radiation will be given to the participant only if they have
not had it prior to the study.
- After the treatment, participants will be asked to return for a follow-up visit 6
weeks, 3 months, every 6 months thereafter for 4 years, then annually to year 10. At
these visits, they will have the following: physical examination; recent medical
history; MRI or CT scan (twice each year) and; chest x-ray or chest CT (twice each
year).
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To evaluate the feasibility of titanium-enclosed and differentially-loaded Y-90 dural brachytherapy plaques in this patient population
10 years
Yes
Thomas F. DeLaney, MD
Principal Investigator
Massachusetts General Hospital
United States: Institutional Review Board
07-007
NCT00706485
July 2007
July 2017
Name | Location |
---|---|
Massachusetts General Hospital | Boston, Massachusetts 02114-2617 |