Radiofrequency Ablation of Pulmonary Tumors Response Evaluation: a Prospective, Intention-to-Treat, Multicenter Clinical Trial
Image-guided RF ablation is accepted as a viable therapeutic choice for patients with
early-stage hepatocellular carcinoma or limited hepatic metastatic disease from colorectal
cancer, when surgery is precluded (1, 2). Recently, RF ablation has been proposed as a
viable option for the treatment of pulmonary malignancies. Experimental studies in animal
tumor models have confirmed the effectiveness of RF ablation in the destruction of
experimentally-induced pulmonary malignancies (3). Pilot clinical investigations have
suggested that the treatment can achieve high proportions of tumor response (4, 5). We
designed a prospective, intention-to-treat, multicenter clinical trial aimed at assessing
feasibility, safety and effectiveness of RF ablation in the treatment of lung malignancies.
Interventional
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
technical success
immediate
No
Riccardo Lencioni, MD
Principal Investigator
University of Pisa, Pisa, Italy
Italy: Ethics Committee
102-00
NCT00690703
July 2001
December 2007
Name | Location |
---|---|
UCLA Medical Center | Los Angeles, California 90095-7059 |