Inclusion Criteria:

- Patients (between the ages of 8 to 65 years) with histologically proven high grade
osteosarcoma of the extremity and relapsed disease after primary line of treatment
who are unsuitable or refuse secondary chemotherapy.

- Patients with advanced disease unable or unwilling to take primary conventional
treatment

- Patients with early or non-metastatic disease who are unable or unwilling to take the
standard chemotherapy.

- Adequate hepatic function defined by total bilirubin not more than 1.5 times the
upper limit of normal (ULN) and SGOT and SGPT not more than 2.5 times the (ULN)

- Adequate renal function defined by the creatinine clearance greater than 50 ml/min,
calculated by cockcroft-Gault formula

Exclusion Criteria:

- Patients who are suitable for second line chemotherapy and can afford it

- Age less than 8 years or greater than 65 years

- Pregnant or lactating women

- Patients who are unable or unwilling to provide blood samples for the drug assays.

- Low grade osteosarcoma

- Patient requiring treatment with CYP3A4 inducers or inhibitors (patients on treatment
for epilepsy or tuberculosis)

- Participation in any investigational drug study within 28 days prior to study
treatment.