Inclusion Criteria:

- Pts have histologically confirmed diagnosis of recurrent/progressive WHO gr III & IV
MG & meet following inclusion criteria:

- Age >18 yrs

- Interval of >4 wks since prior surgery

- Interval of >4 wks since prior external beam radiation therapy (XRT) or chemo, unless
there is unequivocal evidence of progressive disease & pts have recovered from all
anticipated toxicity of most recent therapy

- Karnofsky performance status score >60

- Hematocrit > 29 percent, absolute neutrophil count (ANC) >1,500 cells/microliter,
platelets >100,000 cells/microliter

- Serum creatinine <.5mg/dl, blood urea nitrogen (BUN) <25 mg/dl, serum glutamate
oxaloacetate transaminase (SGOT) & bilirubin <1.5 x upper limit of normal (ULN)

- For pts on corticosteroids, they have been on stable dose for 1 wk prior to entry

- Pts have had prior bevacizumab are eligible however interval of >6 wks must have
elapsed since their last dose

- Signed informed consent approved by Institutional Review Board (IRB) prior to patient
entry;

- If sexually active, pts must agree to take contraceptive measures for duration of
treatments

Exclusion Criteria:

- Prior therapy w either bevacizumab/EGFR-directed agents

- >3 prior recurrences

- Pregnancy/breast feeding

- Co-medication w immuno-suppressive agents other than corticosteroids including but
not limited to cyclosporine, tacrolimus, sirolimus, mycophenolate mofetil

- Evidence of central nervous system (CNS) hemorrhage on baseline MRI on CT scan

- Pts who require therapeutic anti-coagulation

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection requiring IV antibiotics & psychiatric illness/social situations that would
limit compliance w study requirements, or disorders associated w significant
immunocompromised state

- Pts w another primary malignancy that has required treatment within past year

- Pts w acute/chronic renal insufficiency/those w acute renal insufficiency of any
severity due to hepato-renal syndrome/in peri-operative liver transplantation period